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Structure of 1046462-99-0
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4-Nitro-5-(trifluoromethyl)-1H-pyrazole features a strongly electron-deficient pyrazole core stabilized by a para-nitro group and a sterically demanding trifluoromethyl substituent. This combination enhances reactivity in transition-metal-catalyzed coupling processes, enabling efficient incorporation into complex heterocyclic architectures under standard conditions.
4-Nitro-5-(trifluoromethyl)-1H-pyrazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to nitrogen-rich scaffolds via standard functional group interconversions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the nitro functionality facilitates reduction to an amine or participation in coupling reactions. Its bench-stable nature and compatibility with diverse transformations make it a practical choice for synthesizing bioactive compounds and advanced intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: