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Structure of 1248452-50-7
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3-(Trifluoromethyl)-1H-pyrazol-4-amine features a trifluoromethyl group at the 3-position and an amine function at the 4-position of the pyrazole ring, conferring enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and bioactive heterocycles. The compound exhibits bench-stable handling and favorable solubility profiles under standard conditions.
3-(Trifluoromethyl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through palladium-catalyzed couplings and electrophilic substitutions. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the pyrazole amine functionality offers site-specific derivatization for drug discovery applications. The compound exhibits good bench stability and facilitates straightforward purification, supporting scalable synthesis in API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P264-P270-P280-P330-P501
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Lot numbers can be found on the outside label of a product: