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CS-W001157 4
Total: USD 88.00

2-Bromo-6-chloropyridin-3-amine

  • CAS No. 1050501-88-6

  • Cat. No. CS-0054821
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-chloropyridin-3-amine|CS-0054821

Structure of 1050501-88-6

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General Information

  • CAS No. 1050501-88-6
  • Cat. No. CS-0054821
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrClN₂
  • Molecular Weight 207.46
  • Synonym(s) 3-Amino-2-bromo-6-chloropyridine
  • SMILES NC1=CC=C(Cl)N=C1Br

Application

2-Bromo-6-chloropyridin-3-amine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling reactions. The ortho-bromo and meta-chloro substituents provide orthogonal reactivity for sequential transformations, while the primary amine group facilitates derivatization or incorporation into heterocyclic scaffolds. Bench-stable and compatible with standard purification methods, it functions reliably in multistep syntheses requiring regioselective substitution.

Synthesis

  • Route1

    References

    • JANSSEN RandD IRELAND; TAHRI, Abdellah; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; VENDEVILLE, Sandrine Marie Helene; HU, Lili; DEMIN, Samuël Dominique; Cooymans, Ludwig Paul Patent: WO2013/186333 A1, 2013 ; Location in patent: Page/Page column 102 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.0797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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