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Structure of 105285-21-0
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4-(tert-Butyl)-1H-pyrazole is a sterically hindered heterocycle featuring a robust pyrazole core with a bulky tert-butyl group at the 4-position. This substitution enhances stability and modulates solubility, enabling efficient integration into complex molecular architectures. The compound serves as a key scaffold in medicinal chemistry and materials science.
4-(tert-Butyl)-1H-pyrazole serves as a robust heterocyclic building block in medicinal chemistry and materials science, offering enhanced solubility and metabolic stability due to the sterically hindered tert-butyl group. It functions as a versatile scaffold for late-stage functionalization, enabling direct C–H arylation and transition-metal-catalyzed couplings. The pyrazole core exhibits strong hydrogen-bonding capacity and π-stacking potential, making it valuable in targeted small-molecule design. Its bench-stable, crystalline nature facilitates handling and purification, supporting scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: