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CS-W001157 4
Total: USD 88.00

ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylate

  • CAS No. 105404-65-7

  • Cat. No. CS-0036999
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylate|CS-0036999

Structure of 105404-65-7

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Description

Ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate is a fluorinated quinolone derivative featuring a piperazinyl group at C7 and a cyclopropyl moiety at C1. This scaffold integrates enhanced solubility with metabolic stability, enabling efficient incorporation into antibacterial and antifungal lead compounds under standard bench conditions.

Application

Ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate serves as a key intermediate in the synthesis of quinolone-based pharmaceuticals. Its structure integrates a fluorinated quinoline core with a piperazinyl side chain and ester functionality, enabling facile derivatization via nucleophilic substitution or hydrolysis. The compound exhibits bench stability and compatibility with standard coupling protocols, facilitating efficient access to diverse analogs for antibacterial and antiviral screening campaigns.

General Information

  • CAS No. 105404-65-7
  • Cat. No. CS-0036999
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₂₂FN₃O₃
  • Molecular Weight 359.40
  • Synonym(s) 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, ethyl ester
  • SMILES CCOC(=O)C1=CN(C2CC2)C3=CC(=C(C=C3C1=O)F)N4CCNCC4

Computational Chemistry Data

  • TPSA   63.57
  • LogP   2.0618
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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