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CS-W001157 4
Total: USD 88.00

4-Amino-2-chlorobenzonitrile

  • CAS No. 20925-27-3

  • Cat. No. CS-W016289
  • Purity≥98%
  • MDL No.MFCD00035926
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Amino-2-chlorobenzonitrile|CS-W016289

Structure of 20925-27-3

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Description

4-Amino-2-chlorobenzonitrile features a strategically positioned amino group and chloro substituent on a nitrile-bearing benzene scaffold, enabling its use in coupling reactions and as a building block for pharmaceutical intermediates. This electron-rich aryl halide integrates readily into diverse synthetic pathways under standard conditions.

Application

4-Amino-2-chlorobenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via cyclization or coupling reactions. Its ortho-chloro and nitrile groups provide complementary reactivity for palladium-catalyzed cross-couplings and nucleophilic substitution, while the amino functionality allows for derivatization through acylation or diazotization. Bench-stable and readily purified by recrystallization, it functions efficiently in multi-step syntheses requiring functional group tolerance and predictable regiochemistry.

General Information

  • CAS No. 20925-27-3
  • Cat. No. CS-W016289
  • Purity ≥98%
  • MDL No. MFCD00035926
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClN₂
  • Molecular Weight 152.58
  • Synonym(s) benzonitrile, 4-amino-2-chloro-
  • SMILES N#CC1=CC=C(N)C=C1Cl

Computational Chemistry Data

  • TPSA   49.81
  • LogP   1.79388
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312-H315-H319-H331-H335
Precautionary Statements : P264-P270-P330-P405-P501

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