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CS-W001157 4
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(2,5-Dichlorophenyl)methanamine

  • CAS No. 10541-69-2

  • Cat. No. CS-0099747
  • Purity≥98%
  • MDL No.MFCD00052391

*For research and further manufacturing use only, not for direct human use.

(2,5-Dichlorophenyl)methanamine|CS-0099747

Structure of 10541-69-2

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General Information

  • CAS No. 10541-69-2
  • Cat. No. CS-0099747
  • Purity ≥98%
  • MDL No. MFCD00052391
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇Cl₂N
  • Molecular Weight 176.04
  • Synonym(s) Benzenemethanamine, 2,5-dichloro-
  • SMILES NCC1=CC(Cl)=CC=C1Cl

Description

(2,5-Dichlorophenyl)methanamine is a bench-stable arylamine featuring two chlorine substituents at the ortho and para positions relative to the methylene linker. This electron-deficient aromatic scaffold enables direct incorporation into diverse synthetic pathways, particularly in medicinal chemistry and agrochemical development. The molecule's enhanced reactivity profile facilitates efficient coupling reactions under mild conditions, offering a robust platform for building complex heterocyclic systems.

Application

(2,5-Dichlorophenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its dichloro-substituted aromatic core provides enhanced metabolic stability and modulates electronic properties, while the primary amine facilitates straightforward derivatization via amidation, alkylation, and reductive amination. Bench-stable and readily purified, it functions reliably in standard synthetic workflows for API development.

Synthesis

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    • In-stock
      (2,5-Dichlorophenyl)methanamine|CS-0099747
      10541-69-2

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118
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    • In-stock
      (2,5-Dichlorophenyl)methanamine|CS-0099747
      10541-69-2

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 6 p. 1745 - 1758
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 6 p. 1745 - 1758

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2922
Class : 8 (6.1)
Packing Group : Ⅲ
Hazard Statements : H301-H314
Precautionary Statements : P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4521
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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