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Structure of 105763-77-7
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2,4-Dichloro-6-methoxyquinazoline features a halogenated quinazoline core with complementary electron-withdrawing chloro groups and a methoxy substituent. This combination enhances electrophilicity at the C7 position, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The compound exhibits excellent stability under standard bench conditions and serves as a key intermediate in kinase inhibitor synthesis.
2,4-Dichloro-6-methoxyquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern facilitates sequential derivatization at C2 and C4 positions, while the methoxy group enhances solubility and modulates electronic properties. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for high-throughput synthesis of quinazoline-based kinase inhibitors and other bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: