2-Chloroquinazoline

Name: 2-Chloroquinazoline
Brand: ChemScene
Availability: InStock
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CAS No. 6141-13-5
Cat. No. CS-W005337
Purity≥95%
MDL No.MFCD09959715

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 6141-13-5

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Description

2-Chloroquinazoline serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at the 2-position that enhances electrophilicity for nucleophilic substitution. This electron-deficient core integrates readily into kinase inhibitors and targeted therapeutics, offering high reactivity under standard conditions while maintaining bench-stable handling characteristics.

Application

2-Chloroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via palladium-catalyzed cross-coupling reactions. Its electrophilic chlorine atom facilitates efficient substitution with amines, thiols, and arylborons, supporting rapid diversification of quinazoline scaffolds. The compound exhibits excellent bench stability and compatibility with common protecting groups, making it well-suited for modular synthesis of kinase inhibitors and other bioactive heterocycles.

General Information

CAS No. 6141-13-5
Cat. No. CS-W005337
Purity ≥95%
MDL No. MFCD09959715
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClN₂
Molecular Weight 164.59
Synonym(s) Quinazoline, 2-chloro-
SMILES C1=NC(=NC2=C1C=CC=C2)Cl

Computational Chemistry Data

TPSA 25.78
LogP 2.2832
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P280-P405

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

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2-Chloroquinazoline

CAS No. 6141-13-5

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