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Structure of 105806-14-2
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6-Chloro-5-fluoro-2-methylpyrimidin-4(3H)-one features a highly functionalized pyrimidinone core with orthogonal halogen and methyl substituents. This electron-deficient scaffold enables selective coupling in cross-coupling and nucleophilic substitution reactions, offering reliable access to complex heterocyclic architectures under standard conditions.
6-Chloro-5-fluoro-2-methylpyrimidin-4(3H)-one serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based pharmacophores. Its orthogonal halogenation pattern facilitates palladium-catalyzed cross-coupling and nucleophilic substitution reactions, while the enolizable carbonyl and methyl group support further functionalization. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for modular synthesis of heterocyclic APIs and agrochemical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: