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Structure of 1060801-92-4
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3-(Trifluoromethyl)isonicotinaldehyde features a trifluoromethyl group flanking an aldehyde-bearing pyridine ring, delivering enhanced electron-withdrawing character and metabolic stability. This configuration enables direct incorporation into bioactive scaffolds, particularly in kinase inhibitor design and fluorescent probe development. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating straightforward handling in synthetic workflows.
3-(Trifluoromethyl)isonicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles via coupling and condensation reactions. Its electron-deficient pyridine ring enhances reactivity in nucleophilic additions and facilitates transition-metal-catalyzed transformations. The trifluoromethyl group imparts metabolic stability and modulates lipophilicity, making it valuable for optimizing pharmacokinetic properties. Bench-stable and compatible with standard purification methods, it functions reliably in multistep syntheses.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: