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Structure of 116308-35-1
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2-(Trifluoromethyl)nicotinaldehyde features a trifluoromethyl group at the 2-position of the nicotinaldehyde scaffold, enhancing electron-withdrawal and metabolic stability. This electron-deficient aldehyde integrates readily into heterocyclic scaffolds and serves as a key building block in medicinal chemistry campaigns targeting kinase inhibitors and bioactive N-heterocycles.
2-(Trifluoromethyl)nicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of trifluoromethyl-substituted heterocycles and bioactive scaffolds. Its aldehyde functionality facilitates reductive amination, condensation, and nucleophilic addition reactions with high functional group tolerance. The electron-withdrawing trifluoromethyl group enhances metabolic stability and modulates electronic properties, making it valuable for optimizing pharmacokinetic profiles in drug discovery campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: