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CS-W001157 4
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4-Fluoropyridin-3-amine

  • CAS No. 1060804-19-4

  • Cat. No. CS-0188746
  • Molecule weight112.11
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Fluoropyridin-3-amine|CS-0188746

Structure of 1060804-19-4

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General Information

  • CAS No. 1060804-19-4
  • Cat. No. CS-0188746
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅FN₂
  • Molecular Weight 112.11
  • Synonym(s) None
  • SMILES NC1=C(F)C=CN=C1

Description

4-Fluoropyridin-3-amine serves as a key nitrogen-containing building block in medicinal chemistry, featuring a fluorinated pyridine core that enhances metabolic stability and modulates electronic properties. The amine group enables direct coupling reactions, while the fluorine substituent improves membrane permeability and target binding affinity. This compound integrates efficiently into diverse heterocyclic frameworks for drug discovery applications.

Application

4-Fluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its ortho-fluoro substitution. The amine functionality facilitates direct derivatization and salt formation, while the pyridine core provides robust hydrogen-bonding capacity and favorable electronic properties for target engagement. Bench-stable and compatible with standard purification protocols, it functions effectively in the synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.8029
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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