1-Bromo-4-(2,2,2-trifluoroethoxy)benzene

Name: 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene
Brand: ChemScene
Availability: InStock
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CAS No. 106854-77-7
Cat. No. CS-W021309
Purity≥96%
MDL No.MFCD07780193

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1-Bromo-4-(2,2,2-trifluoroethoxy)benzene|CS-W021309

Structure of 106854-77-7

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Description

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene features a bromine substituent and a trifluoroethoxy group positioned para to one another on the benzene ring. This electronic configuration enhances its utility in palladium-catalyzed cross-coupling reactions, where the electron-deficient aryl halide integrates efficiently with diverse nucleophiles. The trifluoroethoxy moiety imparts improved metabolic stability and lipophilicity, beneficial for medicinal chemistry applications.

Application

1-Bromo-4-(2,2,2-trifluoroethoxy)benzene serves as a versatile aryl halide building block in cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The trifluoroethoxy group enhances metabolic stability and modulates electronic properties, while the bromine center provides high reactivity in Pd-catalyzed couplings. Bench-stable and compatible with standard purification protocols, it facilitates streamlined synthesis of fluorinated aromatic scaffolds relevant to agrochemical and pharmaceutical development.

General Information

CAS No. 106854-77-7
Cat. No. CS-W021309
Purity ≥96%
MDL No. MFCD07780193
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆BrF₃O
Molecular Weight 255.03
Synonym(s) UKRORGSYN-BB BBV-081072
SMILES FC(F)(F)COC1=CC=C(Br)C=C1

Computational Chemistry Data

TPSA 9.23
LogP 3.3902
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Ether

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-4-(2,2,2-trifluoroethoxy)benzene

CAS No. 106854-77-7

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