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Structure of 2713-28-2
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2-Fluoro-4-iodophenol features a fluorine atom at the ortho position and an iodine substituent at the para position relative to the phenolic hydroxyl group. This electronic configuration enhances its utility in cross-coupling reactions, where the iodide serves as a reactive handle. The molecule exhibits bench-stable behavior and compatibility with palladium-catalyzed transformations under standard conditions.
2-Fluoro-4-iodophenol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings. Its ortho-fluoro substituent enhances reactivity in nucleophilic aromatic substitution, while the iodo group provides high efficiency in transition-metal-mediated transformations. The phenolic hydroxyl group offers additional functionalization potential and contributes to favorable solubility and purification characteristics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: