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Structure of 106877-20-7
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3-Methoxy-4-(trifluoromethyl)aniline features a trifluoromethyl group that imparts strong electron-withdrawing character, while the methoxy substituent contributes resonance donation. This electronic duality enhances its utility in constructing advanced intermediates for pharmaceuticals and functional materials. The molecule exhibits robust stability under standard handling conditions and integrates readily into coupling reactions.
3-Methoxy-4-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry, enabling direct incorporation of electron-rich aromatic and strongly electron-withdrawing functionalities. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy substituent offers predictable regiochemistry in electrophilic substitution. The aniline moiety facilitates coupling reactions (e.g., Suzuki, Buchwald–Hartwig), and the compound exhibits good bench stability and ease of purification—ideal for constructing complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: