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CS-W001157 4
Total: USD 88.00

4-Bromo-6-(trifluoromethyl)quinoline

  • CAS No. 1070879-32-1

  • Cat. No. CS-0041220
  • Molecule weight276.06
  • Purity≥98%
  • MDL No.MFCD11505113

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-(trifluoromethyl)quinoline|CS-0041220

Structure of 1070879-32-1

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General Information

  • CAS No. 1070879-32-1
  • Cat. No. CS-0041220
  • Purity ≥98%
  • MDL No. MFCD11505113
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₅BrF₃N
  • Molecular Weight 276.06
  • Synonym(s) None
  • SMILES FC(C1=CC=C2N=CC=C(Br)C2=C1)(F)F

Description

4-Bromo-6-(trifluoromethyl)quinoline is a halogenated quinoline derivative featuring a strongly electron-withdrawing trifluoromethyl group at the 6-position, enhancing its reactivity in palladium-catalyzed cross-coupling processes. This bench-stable scaffold integrates readily into complex molecular architectures, particularly in medicinal chemistry and materials science applications requiring fluorinated heterocyclic motifs.

Application

4-Bromo-6-(trifluoromethyl)quinoline serves as a versatile building block in medicinal chemistry and cross-coupling synthesis, enabling the construction of complex heterocyclic scaffolds. Its bromine handle facilitates palladium-catalyzed coupling reactions, while the trifluoromethyl group enhances metabolic stability and modulates lipophilicity. The molecule exhibits excellent bench stability and compatibility with standard reaction conditions, making it ideal for modular synthesis in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   4.0161
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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