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CS-W001157 4
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4,6-Dimethoxy-1,3,5-triazin-2(1H)-one

  • CAS No. 1075-59-8

  • Cat. No. CS-W020622
  • Molecule weight157.13
  • Purity≥95%
  • MDL No.MFCD02932731

*For research and further manufacturing use only, not for direct human use.

4,6-Dimethoxy-1,3,5-triazin-2(1H)-one|CS-W020622

Structure of 1075-59-8

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General Information

  • CAS No. 1075-59-8
  • Cat. No. CS-W020622
  • Purity ≥95%
  • MDL No. MFCD02932731
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃O₃
  • Molecular Weight 157.13
  • Synonym(s) Dimethyl cyanurate
  • SMILES COC1=NC(O)=NC(OC)=N1

Description

4,6-Dimethoxy-1,3,5-triazin-2(1H)-one features a highly reactive triazine core with methoxy groups that enhance solubility and stability under standard conditions. This bench-stable reagent facilitates efficient coupling reactions in peptide synthesis and functional group derivatization, offering reliable performance in complex molecular architectures.

Application

4,6-Dimethoxy-1,3,5-triazin-2(1H)-one serves as a versatile building block in synthetic organic chemistry, enabling efficient amide bond formation and peptide coupling under mild conditions. Its enhanced reactivity and bench stability facilitate clean transformations with excellent functional group tolerance. The molecule functions as a key intermediate in the synthesis of heterocyclic scaffolds and bioactive compounds, particularly in medicinal chemistry applications requiring reliable activation protocols.

Synthesis

  • Route1
    • null|null
      1337923-38-2
    • ~0%
    • In-stock
      N-Acetyl-α-D-glucosamine|CS-0316763
      10036-64-3
    • In-stock
      4,6-Dimethoxy-1,3,5-triazin-2(1H)-one|CS-W020622
      1075-59-8

    References

    • Noguchi, Masato; Nakamura, Miwa; Ohno, Ayaka; Tanaka, Tomonari; Kobayashi, Atsushi; Ishihara, Masaki; Fujita, Masaya; Tsuchida, Akiko; Mizuno, Mamoru; Shoda, Shin-Ichiro Chemical Communications, 2012 , vol. 48, # 45 p. 5560 - 5562
  • Route2

    References

    • Organic Letters, , vol. 1, # 3 p. 463 - 465
  • Route3
    • null|null
      42030-76-2
    • ~%
    • p-Hydroxybenzaldehyde Bisoprolol Impurity|CS-0229513
      123-08-0
    • In-stock
      4,6-Dimethoxy-1,3,5-triazin-2(1H)-one|CS-W020622
      1075-59-8

    References

    • Journal of the American Chemical Society, , vol. 117, # 20 p. 5484 - 5491

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   77.36
  • LogP   -0.4056
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   2

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