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CS-W001157 4
Total: USD 88.00

2,2-Difluorocyclopropanecarboxylic acid

  • CAS No. 107873-03-0

  • Cat. No. CS-B1034
  • Purity≥97%
  • MDL No.MFCD04115828
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,2-Difluorocyclopropanecarboxylic acid|CS-B1034

Structure of 107873-03-0

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Description

This difluorinated cyclopropane carboxylic acid features a strained three-membered ring with two fluorine atoms at the geminal position, conferring enhanced metabolic stability and unique electronic properties. The carboxylic acid group enables direct functionalization or salt formation, facilitating integration into bioactive molecules. Its rigid, electron-deficient structure makes it valuable for probing steric and electronic effects in medicinal chemistry and agrochemical design.

Application

2,2-Difluorocyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of a rigid, electron-withdrawing difluoromethylene group into bioactive scaffolds. Its cyclopropane core imparts conformational constraint, while the carboxylic acid functionality facilitates direct derivatization or coupling reactions. The molecule exhibits good bench stability and is compatible with standard synthetic workflows, making it a practical choice for constructing fluorinated heterocycles and drug-like molecules requiring enhanced metabolic stability.

General Information

  • CAS No. 107873-03-0
  • Cat. No. CS-B1034
  • Purity ≥97%
  • MDL No. MFCD04115828
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄F₂O₂
  • Molecular Weight 122.07
  • Synonym(s) 2,2-Difluorocyclopropane-1-carboxylic Acid
  • SMILES O=C(C1C(F)(F)C1)O

Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.7262
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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