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CS-W001157 4
Total: USD 88.00

2-Fluorocyclopropanecarboxylic acid

  • CAS No. 156816-78-3

  • Cat. No. CS-W006378
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Fluorocyclopropanecarboxylic acid|CS-W006378

Structure of 156816-78-3

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Description

2-Fluorocyclopropanecarboxylic acid features a strained cyclopropane ring bearing a fluorine atom and a carboxylic acid group, enabling unique steric and electronic properties. This configuration imparts enhanced metabolic stability and conformational rigidity, making it valuable for medicinal chemistry applications. The molecule exhibits favorable solubility and handles well under standard bench conditions.

Application

2-Fluorocyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the incorporation of a strained cyclopropane motif with a polar carboxylic acid group. Its enhanced metabolic stability and conformational rigidity facilitate target engagement in bioactive molecule design. The fluorine substituent modulates electronic properties and lipophilicity, while the carboxylic acid enables direct derivatization via amide formation or esterification—key steps in peptide and small-molecule synthesis. Bench-stable and compatible with standard reaction conditions, it supports efficient downstream functionalization in both academic and industrial R&D workflows.

General Information

  • CAS No. 156816-78-3
  • Cat. No. CS-W006378
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅FO₂
  • Molecular Weight 104.08
  • Synonym(s) 2-FLUOROCYCLOPROPANE-1-CARBOXYLIC ACID, MIXTURE OF DIASTEREOMERS
  • SMILES O=C(C1C(F)C1)O

Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.429
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

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