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5-Amino-6-methylpicolinonitrile

  • CAS No. 1079054-78-6

  • Cat. No. CS-0036179
  • Molecule weight133.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Amino-6-methylpicolinonitrile|CS-0036179

Structure of 1079054-78-6

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General Information

  • CAS No. 1079054-78-6
  • Cat. No. CS-0036179
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight 133.15
  • Synonym(s) 5-Amino-6-methyl-2-pyridinecarbonitrile
  • SMILES CC1=NC(=CC=C1N)C#N

Description

5-Amino-6-methylpicolinonitrile features a fused pyridine ring bearing an amino group at C5, a methyl substituent at C6, and a nitrile function at C1. This electron-deficient heterocyclic scaffold integrates readily into synthetic routes for bioactive molecules, offering enhanced solubility and stability under standard conditions.

Application

5-Amino-6-methylpicolinonitrile serves as a versatile building block in synthetic organic chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its ortho-dicyanide motif and amino-methyl substituents offer complementary reactivity for nucleophilic substitution, cyclization, and transition-metal-catalyzed coupling reactions. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      557-21-1
    • In-stock
      3-Amino-6-bromo-2-methylpyridine|CS-D0973
      126325-47-1
    • ~64%
    • In-stock
      5-Amino-6-methylpicolinonitrile|CS-0036179
      1079054-78-6

    References

    • Laboratoires Fournier S.A. Patent: US2007/54955 A1, 2007 ; Location in patent: Page/Page column 5 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.7
  • LogP   0.8439
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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