2-O-DMT-Sulfonyldiethanol phosphoramidite

Name: 2-O-DMT-Sulfonyldiethanol phosphoramidite
Brand: ChemScene
Availability: InStock
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CAS No. 108783-02-4
Cat. No. CS-0311370
Purity≥95%
MDL No.MFCD00036168

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

2-O-DMT-Sulfonyldiethanol phosphoramidite|CS-0311370

Structure of 108783-02-4

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Description

2-O-DMT-Sulfonyldiethanol phosphoramidite delivers a protected hydroxyl handle for site-specific conjugation in oligonucleotide synthesis. The sulfonyl linker provides robust stability under standard deprotection conditions, while the DMT group ensures efficient purification via reverse-phase HPLC. This reagent enables precise incorporation of functionalized nucleosides with minimal side reactions.

Application

2-O-DMT-Sulfonyldiethanol phosphoramidite serves as a key building block for the synthesis of oligonucleotides requiring site-specific modification at the 2'-OH position. Its sulfonyl linker enables efficient, orthogonal protection and facile deprotection under mild conditions, while the DMT group provides robust temporary protection and UV monitoring capability. The phosphoramidite functionality ensures high coupling efficiency in automated solid-phase synthesis, offering excellent stability during storage and reliable performance across diverse sequence contexts.

General Information

CAS No. 108783-02-4
Cat. No. CS-0311370
Purity ≥95%
MDL No. MFCD00036168
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₄H₄₅N₂O₇PS
Molecular Weight 656.77
Synonym(s) None
SMILES N#CCCOP(N(C(C)C)C(C)C)OCCS(=O)(CCOC(C1=CC=C(C=C1)OC)(C2=CC=C(C=C2)OC)C3=CC=CC=C3)=O

Computational Chemistry Data

TPSA 107.32
LogP 6.71968
H_Acceptors 9
H_Donors 0
Rotatable_Bonds 19

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Sulfone

Building Blocks Functional Group Ether

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Nucleosides & Nucleotides Other Protective and Modifying Phosphoramidite Monomers

Chemical Biology Nucleic Acid Chemistry Protected Nucleosides

Chemical Biology Nucleic Acid Chemistry Nucleoside Phosphoramidites

Key Words

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2-O-DMT-Sulfonyldiethanol phosphoramidite

CAS No. 108783-02-4

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