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Structure of 108858-86-2
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1-(4-Aminophenyl)cyclopropane-1-carbonitrile features a rigid cyclopropane ring fused to an aniline moiety, delivering enhanced metabolic stability and conformational restraint. The para-amino and nitrile groups enable strong hydrogen bonding and dipole interactions, facilitating binding to diverse biological targets. This scaffold integrates readily into kinase inhibitors and receptor modulators, offering improved solubility and target engagement under physiological conditions.
1-(4-Aminophenyl)cyclopropane-1-carbonitrile serves as a versatile building block for constructing bioactive heterocycles and pharmaceutical scaffolds. Its cyclopropyl ring imparts conformational rigidity, while the para-aminophenyl and nitrile groups enable diverse functionalization via coupling reactions, electrophilic substitution, and transition-metal-catalyzed transformations. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: