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CS-W001157 4
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6-Methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-amine

  • CAS No. 1092394-15-4

  • Cat. No. CS-0311025
  • Molecule weight164.16
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-amine|CS-0311025

Structure of 1092394-15-4

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General Information

  • CAS No. 1092394-15-4
  • Cat. No. CS-0311025
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₄O
  • Molecular Weight 164.16
  • Synonym(s) 6-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-amine
  • SMILES NC1=NN2C=C(OC)C=CC2=N1

Description

6-Methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-amine features a fused triazolopyridine core with a methoxy group at the 6-position and a primary amine at C2. This electron-rich heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced solubility and metabolic stability. The pendant amine enables direct coupling in peptide or small-molecule conjugation workflows under standard conditions.

Application

6-Methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling rapid access to triazolopyridine scaffolds prevalent in kinase inhibitors and CNS-targeted agents. Its methoxy group enhances solubility and modulates electronic properties, while the amine functionality facilitates straightforward derivatization via acylation, alkylation, or coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for high-throughput synthesis and lead optimization workflows.

Synthesis

  • Route1
    • null|null
      1092394-14-3
    • ~83%
    • In-stock
      6-Methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-amine|CS-0311025
      1092394-15-4

    References

    • US2009/270405 A1, ; Page/Page column 81 ;
  • Route2

    References

    • WO2011/53292 A1, ; WO 2011/053292 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.44
  • LogP   0.3201
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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