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CS-W001157 4
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2-Bromo-5-fluoropyridin-3-ol

  • CAS No. 1093758-87-2

  • Cat. No. CS-0132215
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-fluoropyridin-3-ol|CS-0132215

Structure of 1093758-87-2

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General Information

  • CAS No. 1093758-87-2
  • Cat. No. CS-0132215
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrFNO
  • Molecular Weight 191.99
  • Synonym(s) 2-Bromo-5-fluoro-hydroxypyridine
  • SMILES OC1=CC(F)=CN=C1Br

Description

2-Bromo-5-fluoropyridin-3-ol features a pyridine core functionalized with bromo and fluoro substituents at adjacent positions, enabling selective cross-coupling reactions. The phenolic hydroxyl group enhances polarity and facilitates derivatization, while the electron-deficient ring system supports nucleophilic substitution under mild conditions. This compound serves as a key building block in the synthesis of bioactive heterocycles and pharmaceutical intermediates.

Application

2-Bromo-5-fluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromine site facilitates efficient C–C bond formation, while the fluorine and hydroxyl groups offer strategic points for further functionalization or hydrogen bonding in target molecules. Bench-stable and compatible with standard purification methods, it functions reliably in the synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.6888
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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