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CS-W001157 4
Total: USD 88.00

DMT-dU-CE Phosphoramidite

  • CAS No. 109389-30-2

  • Cat. No. CS-0149454
  • Purity≥98%
  • MDL No.MFCD00036354
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

DMT-dU-CE Phosphoramidite|CS-0149454

Structure of 109389-30-2

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Description

DMT-dU-CE Phosphoramidite delivers a protected uridine derivative with a 5'-dimethoxytrityl group and a 3'-cholesteryl ether linkage, enabling efficient incorporation into oligonucleotides. The cholesteryl moiety enhances duplex stability through hydrophobic interactions, while the DMT group ensures convenient purification and monitoring. This reagent supports robust synthesis under standard conditions.

Application

DMT-dU-CE Phosphoramidite serves as a key building block for the site-specific incorporation of 5-(2-cyanoethyl)-2'-deoxyuridine into oligonucleotides during solid-phase synthesis. Its cyanoethyl protecting group enables efficient deprotection under mild basic conditions, ensuring high fidelity and minimal side reactions. The dimethoxytrityl (DMT) group provides excellent UV monitoring and facilitates purification via chromatography. This phosphoramidite exhibits robust stability, predictable coupling efficiency, and broad compatibility with standard synthesis protocols, making it ideal for the preparation of modified DNA sequences in research and diagnostics.

General Information

  • CAS No. 109389-30-2
  • Cat. No. CS-0149454
  • Purity ≥98%
  • MDL No. MFCD00036354
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₉H₄₇N₄O₈P
  • Molecular Weight 730.79
  • Synonym(s) None
  • SMILES COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H](N5C(NC(C=C5)=O)=O)O4

Computational Chemistry Data

  • TPSA   137.27
  • LogP   6.51118
  • H_Acceptors   11
  • H_Donors   1
  • Rotatable_Bonds   17

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H317-H319-H335-H360
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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