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CS-W001157 4
Total: USD 88.00

4-Ethynylpyridin-2-amine

  • CAS No. 1094679-27-2

  • Cat. No. CS-0059695
  • Molecule weight118.14
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Ethynylpyridin-2-amine|CS-0059695

Structure of 1094679-27-2

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General Information

  • CAS No. 1094679-27-2
  • Cat. No. CS-0059695
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂
  • Molecular Weight 118.14
  • Synonym(s) 4-Ethynyl-pyridin-2-ylamine
  • SMILES C#CC1=CC(N)=NC=C1

Description

4-Ethynylpyridin-2-amine features a reactive alkyne group conjugated to a pyridine amine, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and materials assembly. This bench-stable, moisture-tolerant reagent integrates readily into functional molecular architectures with minimal purification.

Application

4-Ethynylpyridin-2-amine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The terminal alkyne moiety exhibits excellent stability and compatibility with diverse reaction conditions, while the pyridine-amino motif provides orthogonal reactivity for further derivatization. Its bench-stable nature and ease of purification make it well-suited for modular synthesis applications in medicinal chemistry and materials science.

Synthesis

  • Route1

    References

    • Ni, Ming Hong; Esposito, Emiliano; Castorina, Massimo; Pozzo, Alma Dal Letters in Drug Design and Discovery, 2011 , vol. 8, # 5 p. 401 - 405
  • Route2
    • 4-((Trimethylsilyl)ethynyl)pyridin-2-amine|CS-0276221
      865798-13-6
    • ~%
    • In-stock
      4-Ethynylpyridin-2-amine|CS-0059695
      1094679-27-2

    References

    • Ni, Ming Hong; Esposito, Emiliano; Castorina, Massimo; Pozzo, Alma Dal Letters in Drug Design and Discovery, 2011 , vol. 8, # 5 p. 401 - 405

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.6451
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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