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Total: USD 88.00

6-Chloro-5-(trifluoromethyl)nicotinaldehyde

  • CAS No. 1113049-90-3

  • Cat. No. CS-0044880
  • Purity≥95%
  • MDL No.MFCD18258310

*For research and further manufacturing use only, not for direct human use.

6-Chloro-5-(trifluoromethyl)nicotinaldehyde|CS-0044880

Structure of 1113049-90-3

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General Information

  • CAS No. 1113049-90-3
  • Cat. No. CS-0044880
  • Purity ≥95%
  • MDL No. MFCD18258310
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃ClF₃NO
  • Molecular Weight 209.55
  • Synonym(s) 2-Chloro-3-trifluoromethylpyridine-5-carboxaldehyde
  • SMILES O=CC1=CN=C(Cl)C(C(F)(F)F)=C1

Description

6-Chloro-5-(trifluoromethyl)nicotinaldehyde delivers a potent electron-deficient heteroaromatic scaffold ideal for cross-coupling and condensation reactions. The trifluoromethyl group enhances lipophilicity and metabolic stability, while the chloro substituent enables further functionalization. This bench-stable aldehyde integrates readily into complex molecular architectures under standard conditions.

Application

6-Chloro-5-(trifluoromethyl)nicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via condensation and coupling reactions. Its electron-deficient pyridine core supports diverse functionalization, while the aldehyde group facilitates facile derivatization. Bench-stable and compatible with standard purification methods, it functions effectively in multistep syntheses requiring high regiochemical control and functional group tolerance.

Synthesis

  • Route1
    • In-stock
      2-Chloro-5-iodo-3-(trifluoromethyl)pyridine|CS-W021659
      887707-25-7
    • null|null
      109-94-4
    • ~%
    • In-stock
      6-Chloro-5-(trifluoromethyl)nicotinaldehyde|CS-0044880
      1113049-90-3

    References

    • WO2009/18657 A1, ; Page/Page column 71 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.5663
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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