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CS-W001157 4
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4,6-Dimethoxypyrimidin-5-methylamine

  • CAS No. 1118786-90-5

  • Cat. No. CS-0186926
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,6-Dimethoxypyrimidin-5-methylamine|CS-0186926

Structure of 1118786-90-5

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General Information

  • CAS No. 1118786-90-5
  • Cat. No. CS-0186926
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁N₃O₂
  • Molecular Weight 169.18
  • Synonym(s) (4,6-Dimethoxypyrimidin-5-yl)methanamine
  • SMILES COC1=C(CN)C(=NC=N1)OC

Description

4,6-Dimethoxypyrimidin-5-methylamine features a pyrimidine core bearing methoxy groups at positions 4 and 6, enhancing solubility and metabolic stability. The methylamine substituent at C5 provides a reactive handle for conjugation, enabling efficient incorporation into bioactive scaffolds. This compound serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and antiviral agents.

Application

4,6-Dimethoxypyrimidin-5-methylamine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its ortho-dimethoxy functionality enhances stability and facilitates regioselective functionalization, while the methylamine group offers direct coupling potential. The compound exhibits excellent bench stability and compatibility with standard amine protection and cross-coupling protocols, making it well-suited for modular synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.26
  • LogP   -0.0475
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

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