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CS-W001157 4
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Br-CO-piperazine-Boc

  • CAS No. 112257-12-2

  • Cat. No. CS-0197887
  • Molecule weight307.19
  • Purity≥97%
  • MDL No.MFCD16990579

*For research and further manufacturing use only, not for direct human use.

Br-CO-piperazine-Boc|CS-0197887

Structure of 112257-12-2

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General Information

  • CAS No. 112257-12-2
  • Cat. No. CS-0197887
  • Purity ≥97%
  • MDL No. MFCD16990579
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉BrN₂O₃
  • Molecular Weight 307.19
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCN(C(=O)CBr)CC1

Description

tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate features a bromoacetyl group attached to a piperazine scaffold, enabling direct conjugation in synthetic workflows. This bench-stable reagent facilitates rapid installation of reactive acyl moieties under mild conditions, serving as a key intermediate in the construction of bioactive molecules and peptidomimetics.

Application

tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate serves as a versatile building block for the synthesis of piperazine-based pharmaceutical intermediates. The bromoacetyl group enables efficient alkylation and conjugate addition reactions, while the tert-butyl ester provides stability and convenient deprotection under mild acidic conditions. Its compatibility with diverse functional groups facilitates straightforward incorporation into complex molecular architectures, making it ideal for medicinal chemistry campaigns requiring rapid scaffold diversification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.85
  • LogP   1.4606
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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