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Structure of 1126650-66-5
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tert-Butyl 3-fluoro-3-(hydroxymethyl)azetidine-1-carboxylate features a strained azetidine core bearing a fluorine atom and a hydroxymethyl group, enabling selective functionalization. The tert-butyl ester facilitates purification and handling, while the hydroxymethyl moiety offers a site for further derivatization. This scaffold delivers enhanced metabolic stability and membrane permeability in bioactive molecule design.
tert-Butyl 3-fluoro-3-(hydroxymethyl)azetidine-1-carboxylate serves as a versatile building block for the synthesis of fluorinated azetidine-containing scaffolds. The pendant hydroxymethyl group enables straightforward functionalization via oxidation, protection, or coupling reactions, while the fluorine atom imparts enhanced metabolic stability and modulates electronic properties. The tert-butyl carbamate provides excellent stability and ease of removal under mild acidic conditions, facilitating downstream transformations in medicinal chemistry and process development.
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Lot numbers can be found on the outside label of a product: