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CS-W001157 4
Total: USD 88.00

3',4',5'-Trimethoxyacetophenone

  • CAS No. 1136-86-3

  • Cat. No. CS-0075988
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3',4',5'-Trimethoxyacetophenone|CS-0075988

Structure of 1136-86-3

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Description

3',4',5'-Trimethoxyacetophenone features a highly electron-rich aromatic ring stabilized by three methoxy groups, enabling efficient coupling in cross-coupling reactions. The acetyl moiety provides a reactive carbonyl for nucleophilic addition or reduction. Bench-stable and moisture-tolerant, it integrates seamlessly into complex synthesis workflows.

Application

3',4',5'-Trimethoxyacetophenone serves as a versatile building block in medicinal chemistry and natural product synthesis, offering high functional group tolerance and bench stability. Its three methoxy groups enhance solubility and electron-donating character, facilitating electrophilic substitution and transition-metal-catalyzed coupling reactions. The acetyl functionality enables facile transformations including aldol condensations, reductions, and nucleophilic additions, making it a practical scaffold for constructing complex aromatic architectures.

General Information

  • CAS No. 1136-86-3
  • Cat. No. CS-0075988
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄O₄
  • Molecular Weight 210.23
  • Synonym(s) 3,4,5-Trimethoxyacetophenone
  • SMILES O=C(C)C1=CC(OC)=C(OC)C(OC)=C1

Computational Chemistry Data

  • TPSA   44.76
  • LogP   1.915
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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