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Structure of 113845-68-4
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1-(4-(Trifluoromethyl)phenyl)pyrrolidine features a trifluoromethyl-substituted phenyl group linked to a pyrrolidine ring, delivering enhanced lipophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules, particularly in medicinal chemistry applications where electron-withdrawing fluorinated aromatics improve target affinity and membrane permeability. The compound exhibits bench-stable handling characteristics and compatibility with diverse synthetic transformations.
1-(4-(Trifluoromethyl)phenyl)pyrrolidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its trifluoromethyl aryl group enhances metabolic stability and lipophilicity, while the pyrrolidine moiety provides a basic nitrogen for salt formation and hydrogen bonding. The compound exhibits excellent bench stability and compatibility with common synthetic transformations, facilitating efficient route development in API discovery programs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P302+P352-P304+P340
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Lot numbers can be found on the outside label of a product: