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CS-W001157 4
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tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate

  • CAS No. 114214-73-2

  • Cat. No. CS-0048376
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD18917057

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate|CS-0048376

Structure of 114214-73-2

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General Information

  • CAS No. 114214-73-2
  • Cat. No. CS-0048376
  • Purity ≥97%
  • MDL No. MFCD18917057
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight None
  • Synonym(s) 1-Pyrrolidinecarboxylic acid, 3-(aminomethyl)-3-hydroxy-, 1,1-dimethylethyl ester
  • SMILES CC(C)(C)OC(=O)N1CCC(O)(CN)C1

Description

tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate features a sterically hindered pyrrolidine core with a pendant hydroxyl and aminomethyl group, enabling selective functionalization. The protected amine and stable tert-butyl ester facilitate modular synthesis in medicinal chemistry, while the hydroxyl moiety supports downstream derivatization. This scaffold integrates readily into bioactive molecule frameworks under standard conditions.

Application

tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate serves as a versatile pyrrolidine-based building block for medicinal chemistry and peptide synthesis. The pendant hydroxyl group enables selective derivatization, while the protected amine and tert-butyl carbamate facilitate orthogonal functionalization. Its bench-stable nature and compatibility with standard coupling conditions make it ideal for constructing complex heterocyclic scaffolds and bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   75.79
  • LogP   0.317
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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