2′,2′-Difluorodeoxyuridine

Name: 2′,2′-Difluorodeoxyuridine
Brand: ChemScene
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CAS No. 114248-23-6
Cat. No. CS-0146489
Purity≥98%
MDL No.MFCD00871912

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Useful derivative for the synthesis of phosphoserine peptides by the Fmoc SPPS global phosphorylation methodology. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPS

Application

2′,2′-Difluorodeoxyuridine serves as a key nucleoside building block for the synthesis of antiviral and anticancer agents. Its difluorinated sugar moiety enhances metabolic stability and facilitates incorporation into DNA, enabling targeted inhibition of viral polymerases and DNA replication enzymes. The compound exhibits robust bench stability and compatibility with standard phosphorylation and coupling protocols, making it a reliable intermediate in medicinal chemistry workflows involving nucleoside analogs.

General Information

CAS No. 114248-23-6
Cat. No. CS-0146489
Purity ≥98%
MDL No. MFCD00871912
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀F₂N₂O₅
Molecular Weight 264.18
Synonym(s) dFdU; 2',2'-Difluoro-2'-deoxyuridine
SMILES O=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)C=CC1=O

Computational Chemistry Data

TPSA 104.55
LogP -1.5775
H_Acceptors 6
H_Donors 3
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Bioactive Molecules Bioactive Small Molecules

Life Science Nucleosides & Nucleotides Halogen-modified Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

Key Words

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2′,2′-Difluorodeoxyuridine

CAS No. 114248-23-6

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