N-(5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

Name: N-(5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
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CAS No. 1142943-96-1
Cat. No. CS-0028305
Molecule weight281.11
Purity≥97%
MDL No.MFCD28502349

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N-(5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide|CS-0028305

Structure of 1142943-96-1

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General Information

CAS No. 1142943-96-1
Cat. No. CS-0028305
Purity ≥97%
MDL No. MFCD28502349
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₉BrN₄O
Molecular Weight 281.11
Synonym(s) cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide
SMILES O=C(C1CC1)NC2=NN3C(Br)=CC=CC3=N2

Description

N-(5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide features a rigid, electron-deficient triazolopyridine core paired with a sterically constrained cyclopropylcarboxamide group. This combination imparts enhanced metabolic stability and favorable binding geometry for targeted covalent inhibition in kinase-directed drug discovery.

Application

N-(5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide serves as a versatile building block for constructing bioactive heterocycles, leveraging the bromo-substituted triazolopyridine core for palladium-catalyzed cross-coupling reactions. The cyclopropanecarboxamide moiety provides structural rigidity and favorable pharmacophoric properties, while the amide functionality offers stability and compatibility with diverse synthetic transformations. This compound exhibits bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 59.29
LogP 1.8403
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Triazole compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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N-(5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

CAS No. 1142943-96-1

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