E3 ligase Ligand 64

Name: E3 ligase Ligand 64
Brand: ChemScene
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CAS No. 2760850-50-6
Cat. No. CS-0774355
Molecule weight341.14
Purity≥97%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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General Information

CAS No. 2760850-50-6
Cat. No. CS-0774355
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₀BrFN₄O₂
Molecular Weight 341.14
Synonym(s) None
SMILES O=C1NC(CCN1C2=NN(C)C3=C2C=C(F)C(Br)=C3)=O

Description

E3 ligase Ligand 64 is a potent, bench-stable small molecule that selectively engages target E3 ubiquitin ligases to drive site-specific protein degradation. This compound features a reactive warhead optimized for covalent conjugation and integrates seamlessly into PROTAC architectures. Its electron-deficient core enhances binding affinity and enables efficient ubiquitin transfer under physiological conditions.

Application

E3 ligase Ligand 64 serves as a well-characterized molecular scaffold for targeted protein degradation, enabling selective recruitment of E3 ubiquitin ligase complexes. It functions as a high-affinity binder in PROTAC architectures, facilitating efficient ubiquitination and subsequent proteasomal degradation of target proteins. Its stability, synthetic tractability, and demonstrated utility in modular degrader design make it a practical tool for validating therapeutic targets in chemical biology workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 67.23
LogP 1.9212
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Urea

Building Blocks Functional Group Amide

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Indazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Other aliphatic heterocycles compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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E3 ligase Ligand 64

CAS No. 2760850-50-6

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