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CS-W001157 4
Total: USD 88.00

4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

  • CAS No. 1152441-29-6

  • Cat. No. CS-0041683
  • Purity≥97%
  • MDL No.MFCD16996293
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline|CS-0041683

Structure of 1152441-29-6

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Description

4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline features a boronate ester group paired with a fluorinated aromatic ring, enabling reliable cross-coupling in palladium-catalyzed reactions. The tetramethyl-substituted dioxaborolane enhances stability and solubility under standard conditions. This compound integrates seamlessly into Suzuki-Miyaura coupling workflows for constructing complex arylated scaffolds.

Application

4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The arylboronate group enables efficient C–C bond formation under mild conditions, while the fluorinated aniline functionality provides a handle for further derivatization. Bench-stable and compatible with diverse functional groups, it facilitates rapid access to substituted biaryl scaffolds in medicinal chemistry and materials science applications.

General Information

  • CAS No. 1152441-29-6
  • Cat. No. CS-0041683
  • Purity ≥97%
  • MDL No. MFCD16996293
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇BFNO₂
  • Molecular Weight 237.08
  • Synonym(s) 5-Amino-2-fluorophenylboronic acid pinacol ester
  • SMILES NC1=CC=C(F)C(B2OC(C)(C)C(C)(C)O2)=C1

Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.7071
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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