3-Chloro-4-iodopyridin-2-amine

Name: 3-Chloro-4-iodopyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1152617-24-7
Cat. No. CS-0035899
Purity≥97%
MDL No.MFCD22627829

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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3-Chloro-4-iodopyridin-2-amine|CS-0035899

Structure of 1152617-24-7

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Description

3-Chloro-4-iodopyridin-2-amine features a halogenated pyridine core with complementary chlorine and iodine substituents at adjacent positions, enabling efficient cross-coupling transformations. This electron-deficient heterocycle integrates readily into complex scaffolds, offering enhanced reactivity in palladium-catalyzed processes. The amine group provides a handle for derivatization, supporting modular synthesis of bioactive compounds.

Application

3-Chloro-4-iodopyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The chloro group facilitates nucleophilic substitution, while the iodo moiety supports efficient coupling with boronic acids, amines, and other nucleophiles. Its bench-stable nature and orthogonal functionalization profile make it ideal for constructing complex heterocyclic scaffolds in API development.

General Information

CAS No. 1152617-24-7
Cat. No. CS-0035899
Purity ≥97%
MDL No. MFCD22627829
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClIN₂
Molecular Weight 254.46
Synonym(s) 3-Chloro-4-iodo-2-pyridinamine
SMILES NC1=NC=CC(I)=C1Cl

Computational Chemistry Data

TPSA 38.91
LogP 1.9218
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Iodide

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Drug Discovery Cancer SHP2

Key Words

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3-Chloro-4-iodopyridin-2-amine

CAS No. 1152617-24-7

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