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CS-W001157 4
Total: USD 88.00

N-methyl-1H-pyrazole-4-carboxamide

  • CAS No. 1154383-52-4

  • Cat. No. CS-W000339
  • Molecule weight125.13
  • Purity≥98%
  • MDL No.MFCD12142818

*For research and further manufacturing use only, not for direct human use.

N-methyl-1H-pyrazole-4-carboxamide|CS-W000339

Structure of 1154383-52-4

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General Information

  • CAS No. 1154383-52-4
  • Cat. No. CS-W000339
  • Purity ≥98%
  • MDL No. MFCD12142818
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃O
  • Molecular Weight 125.13
  • Synonym(s) None
  • SMILES CNC(=O)c1cn[nH]c1

Description

N-methyl-1H-pyrazole-4-carboxamide features a pyrazole ring bearing a carboxamide and N-methyl substituent, delivering enhanced solubility and metabolic stability. This scaffold integrates efficiently into bioactive molecule design, particularly in kinase inhibitors and CNS-targeted therapeutics. The para-substituted carboxamide enables robust hydrogen bonding interactions in binding pockets.

Application

N-Methyl-1H-pyrazole-4-carboxamide serves as a versatile building block in medicinal chemistry, enabling rapid access to pyrazole-based pharmacophores. Its amide functionality offers enhanced metabolic stability and favorable solubility profiles, while the N-methyl group improves membrane permeability. The compound reacts reliably in standard coupling protocols and functions effectively in heterocyclic scaffold elaboration, facilitating efficient synthesis of target molecules for drug discovery programs.

Synthesis

  • Route1
    • In-stock
      Ethyl 1H-pyrazole-4-carboxylate|CS-D1524
      37622-90-5
    • null|null
      74-89-5
    • ~%
    • In-stock
      N-methyl-1H-pyrazole-4-carboxamide|CS-W000339
      1154383-52-4

    References

    • RELIABLE BIOPHARMACEUTICAL CORPORATION; WOOLDRIDGE, Luzviminda, T.; MA, Chun; NADJI, Sourena Patent: WO2012/149196 A1, 2012 ; Location in patent: Page/Page column 15; 16 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   57.78
  • LogP   -0.2307
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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