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CS-W001157 4
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5'-Bromospiro[cyclopentane-1,3'-indoline]

  • CAS No. 1160247-93-7

  • Cat. No. CS-0038803
  • Molecule weight252.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5'-Bromospiro[cyclopentane-1,3'-indoline]|CS-0038803

Structure of 1160247-93-7

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General Information

  • CAS No. 1160247-93-7
  • Cat. No. CS-0038803
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄BrN
  • Molecular Weight 252.15
  • Synonym(s) 5-Bromospiro[1,2-dihydroindole-3,1'-cyclopentane
  • SMILES C1CCC2(C1)CNC3=C2C=C(C=C3)Br

Description

5'-Bromospiro[cyclopentane-1,3'-indoline] features a rigid spirocyclic framework integrating a brominated cyclopentane with an indoline moiety, enabling direct functionalization at the 5'-position. This scaffold delivers enhanced metabolic stability and spatial control for medicinal chemistry applications.

Application

5'-Bromospiro[cyclopentane-1,3'-indoline] serves as a versatile building block for the synthesis of complex indoline-containing scaffolds. The bromine atom at the 5' position enables efficient cross-coupling reactions, facilitating C–C bond formation under standard palladium-catalyzed conditions. Its spirocyclic framework imparts rigidity and stereochemical control, enhancing structural diversity in medicinal chemistry applications. Bench-stable and amenable to purification via flash chromatography, it functions reliably in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.6864
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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