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CS-W001157 4
Total: USD 88.00

3-bromo-4-fluoropyridine

  • CAS No. 116922-60-2

  • Cat. No. CS-W000819
  • Purity≥97%
  • MDL No.MFCD04114101

*For research and further manufacturing use only, not for direct human use.

3-bromo-4-fluoropyridine|CS-W000819

Structure of 116922-60-2

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General Information

  • CAS No. 116922-60-2
  • Cat. No. CS-W000819
  • Purity ≥97%
  • MDL No. MFCD04114101
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrFN
  • Molecular Weight 175.99
  • Synonym(s) 4-FLUORO-3-BROMOPYRIDINE
  • SMILES Fc1ccncc1Br

Description

3-Bromo-4-fluoropyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. The electron-deficient ring enables efficient palladium-catalyzed transformations, while the bromo and fluoro substituents offer orthogonal reactivity. This scaffold facilitates rapid diversification in medicinal chemistry and materials synthesis under standard conditions.

Application

3-Bromo-4-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromine center facilitates efficient Suzuki, Stille, or Negishi couplings, while the fluorine enhances metabolic stability and modulates electronic properties in target molecules. Its bench-stable solid form supports straightforward handling and purification, making it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9832
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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