6-Chloro-2-(trifluoromethyl)pyridin-3-amine

Name: 6-Chloro-2-(trifluoromethyl)pyridin-3-amine
Brand: ChemScene
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CAS No. 117519-13-8
Cat. No. CS-0054544
Purity≥98%
MDL No.MFCD18261523

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Chloro-2-(trifluoromethyl)pyridin-3-amine|CS-0054544

Structure of 117519-13-8

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Description

6-Chloro-2-(trifluoromethyl)pyridin-3-amine delivers a potent electron-deficient pyridine scaffold with orthogonal functional handles. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro substituent enables palladium-catalyzed coupling reactions. This molecule serves as a key building block in medicinal chemistry for targeted kinase inhibitors and bioactive heterocycles.

Application

6-Chloro-2-(trifluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The chloro group facilitates C–C and C–N bond formation under standard conditions, while the trifluoromethyl and amine functionalities offer enhanced metabolic stability and hydrogen-bonding capacity. Bench-stable and compatible with common protecting groups, it supports scalable synthesis of kinase inhibitors and other bioactive molecules.

General Information

CAS No. 117519-13-8
Cat. No. CS-0054544
Purity ≥98%
MDL No. MFCD18261523
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₃N₂
Molecular Weight 196.56
Synonym(s) None
SMILES NC1=CC=C(N=C1C(F)(F)F)Cl

Computational Chemistry Data

TPSA 38.91
LogP 2.336
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3259
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-2-(trifluoromethyl)pyridin-3-amine

CAS No. 117519-13-8

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