3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine

Name: 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine
Brand: ChemScene
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CAS No. 118430-73-2
Cat. No. CS-0022257
Purity≥97%
MDL No.MFCD00068002

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine|CS-0022257

Structure of 118430-73-2

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General Information

CAS No. 118430-73-2
Cat. No. CS-0022257
Purity ≥97%
MDL No. MFCD00068002
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₅N₃
Molecular Weight 153.22
Synonym(s) 3-tert-Butyl-1-methyl-1H-pyrazol-5-amine
SMILES CC(C1=NN(C(N)=C1)C)(C)C

Description

This pyrazole derivative features a sterically hindered tert-butyl group and a methyl substituent at the 1-position, enhancing stability and solubility. The para-amine functionality enables direct coupling in cross-coupling reactions or as a building block in medicinal chemistry. Designed for robust performance under standard conditions.

Application

3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrazole-based heterocycles through standard coupling and functionalization protocols. Its tert-butyl and methyl substituents provide steric shielding and enhanced bench stability, while the primary amine facilitates straightforward derivatization via amidation, alkylation, or electrophilic substitution. The compound exhibits excellent solubility and purification compatibility in routine synthetic workflows.

Synthesis

Route1
- In-stock
  
  59997-51-2
- 60-34-4
- ~95%
- In-stock
  
  118430-73-2
References
- Dumas, Jacques; Hatoum-Mokdad, Holia; Sibley, Robert N; Smith, Roger A; Scott, William J; Khire, Uday; Lee, Wendy; Wood, Jill; Wolanin, Donald; Cooley, Jeffrey; Bankston, Donald; Redman, Aniko M; Schoenleber, Robert; Caringal, Yolanda; Gunn, David; Romero, Romulo; Osterhout, Martin; Paulsen, Holger; Housley, Timothy J; Wilhelm, Scott M; Pirro, John; Chien, Du-Shieng; Ranges, Gerald E; Shrikhande, Alka; Muzsi, Andrew; Bortolon, Elizabeth; Wakefield, Jean; Gianpaolo Ostravage, Cynthia; Bhargava, Ajay; Chau, Thuy Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 12 p. 1559 - 1562

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 43.84
LogP 1.2998
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

118430-73-2 sigma118430-73-2 manufacturer118430-73-2 price118430-73-2 structure118430-73-2 SDSbuy 118430-73-2118430-73-2 supplier118430-73-2 uses118430-73-2 molecular weightprice of 118430-73-2118430-73-2 chemical name formula of 118430-73-2

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3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine

CAS No. 118430-73-2

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