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Structure of 1186609-07-3
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This pyrazole derivative features a 2,2-difluorocyclopropyl group that enhances metabolic stability and lipophilicity. The amine functionality at the C3 position enables direct coupling in medicinal chemistry campaigns. Designed for synthetic accessibility, it integrates readily into bioactive scaffolds requiring constrained cyclopropyl motifs with tunable electronic properties.
5-(2,2-Difluorocyclopropyl)-1H-pyrazol-3-amine serves as a versatile building block for medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. The difluorocyclopropyl group imparts enhanced metabolic stability and modulates electronic properties, while the pyrazole amine functionality facilitates facile derivatization via amidation, alkylation, or transition-metal-catalyzed cross-coupling. Its bench-stable solid form and compatibility with diverse reaction conditions make it well-suited for iterative synthesis campaigns in drug discovery.
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: