Oxazolo[5,4-b]pyridin-2-amine

Name: Oxazolo[5,4-b]pyridin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 118767-91-2
Cat. No. CS-0309245
Purity≥96%
MDL No.MFCD15526653

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Oxazolo[5,4-b]pyridin-2-amine|CS-0309245

Structure of 118767-91-2

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Description

Oxazolo[5,4-b]pyridin-2-amine features a fused heterocyclic core combining oxazole and pyridine rings, delivering enhanced stability and tunable electronic properties. This scaffold integrates readily into medicinal chemistry campaigns, serving as a privileged building block for kinase inhibitors and targeted therapeutics. The amine functionality enables direct derivatization under standard coupling conditions.

Application

Oxazolo[5,4-b]pyridin-2-amine serves as a privileged heterocyclic scaffold in medicinal chemistry, enabling rapid access to bioactive molecules through its inherent nitrogen-rich architecture and favorable metabolic stability. The compound functions as a versatile building block for constructing kinase inhibitors and other targeted therapeutics, exhibiting excellent bench stability and compatibility with standard coupling reactions. Its ortho-positioned amine facilitates direct derivatization, while the fused oxazole-pyridine system supports diverse functional group tolerance, making it well-suited for high-throughput library synthesis and lead optimization campaigns.

General Information

CAS No. 118767-91-2
Cat. No. CS-0309245
Purity ≥96%
MDL No. MFCD15526653
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅N₃O
Molecular Weight 135.12
Synonym(s) Oxazolo[5,4-b]pyridine, 2-amino- (6CI)
SMILES N1=CC=CC=2N=C(OC12)N

Computational Chemistry Data

TPSA 64.94
LogP 0.805
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Oxazole compounds

Key Words

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Oxazolo[5,4-b]pyridin-2-amine

CAS No. 118767-91-2

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