Propargyl-PEG8-NH2

Name: Propargyl-PEG8-NH2
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1196732-52-1
Cat. No. CS-0105432
Purity≥98%
MDL No.MFCD28334507

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1196732-52-1

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Description

Propargyl-PEG8-NH2 features a terminal alkyne group conjugated to a hydrophilic PEG8 spacer and primary amine functionality. This trifunctional scaffold enables site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition, while the PEG8 chain imparts enhanced solubility and reduced non-specific binding in aqueous environments.

Application

Propargyl-PEG8-NH₂ serves as a versatile bifunctional linker for bioconjugation and materials chemistry, combining a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC) with a primary amine for amide coupling. The eight-ethylene glycol spacer enhances solubility and reduces non-specific binding, while the propargyl group offers high reactivity under mild conditions. This compound enables efficient conjugation in peptide labeling, polymer functionalization, and drug delivery systems with excellent stability and ease of purification.

General Information

CAS No. 1196732-52-1
Cat. No. CS-0105432
Purity ≥98%
MDL No. MFCD28334507
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₉H₃₇NO₈
Molecular Weight 407.50
Synonym(s) None
SMILES C#CCOCCOCCOCCOCCOCCOCCOCCOCCN

Computational Chemistry Data

TPSA 99.86
LogP -0.2889
H_Acceptors 9
H_Donors 1
Rotatable_Bonds 24

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Other Classifications

Building Blocks Functional Group PEG

Building Blocks Skeleton Fatty chain compounds

Life Science Linker Alkyne PEG

Life Science Linker Amino PEG

Life Science Linker Propargyl PEG

Life Science ADC Related Compound Non-cleavable linker

Life Science Click Chemistry Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry PEG Azides/Alkynes

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Conjugation Chemistry/Click Chemistry PEG Azides/Alkynes

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

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Propargyl-PEG8-NH2

CAS No. 1196732-52-1

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