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Structure of 120158-03-4
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tert-Butyl (2-chloroacetyl)carbamate delivers a reactive chloroacetyl group for site-specific protein modification. This bench-stable reagent features a protected amine and an electrophilic carbonyl, enabling efficient coupling under mild conditions. The tert-butyl carbamate moiety ensures high stability during storage and handling, while the chlorine atom facilitates nucleophilic displacement at lysine residues.
tert-Butyl (2-chloroacetyl)carbamate serves as a stable, bench-ready chloroacetylating agent that facilitates the selective introduction of the ClCH₂C(O)— group into amine-containing substrates. Its tert-butyl carbamate moiety provides excellent stability and ease of removal under mild acidic conditions, enabling straightforward deprotection after functionalization. The reagent exhibits high functional group tolerance and is widely employed in the synthesis of peptide analogs and heterocyclic scaffolds where controlled acylation is required.
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GHS Pictogram :
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GHS No : GHS06,GHS08
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331-H341
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: