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Structure of 1202245-65-5
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4-Ethynyltetrahydro-2H-pyran offers a reactive alkyne handle tethered to a stable tetrahydrolactone scaffold, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer functionalization. The pyran ring provides conformational rigidity and enhanced solubility in polar organic solvents.
4-Ethynyltetrahydro-2H-pyran serves as a versatile synthetic building block for the construction of heterocyclic scaffolds and bioactive molecules. Its terminal alkyne functionality enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC) and Sonogashira coupling, while the tetrahydro-2H-pyran ring provides metabolic stability and favorable lipophilicity. The compound exhibits excellent bench stability, ease of handling, and compatibility with diverse functional groups, making it ideal for modular synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P210-P243-P273-P403
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Lot numbers can be found on the outside label of a product: