Lot numbers can be found on the outside label of a product:
2-(Tetrahydro-2H-pyran-4-yl)ethanol
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CAS No. 4677-18-3
- Cat. No. CS-0017747
- Purity≥97%
- MDL No.MFCD00129068
*For research and further manufacturing use only, not for direct human use.
Structure of 4677-18-3
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General Information
- CAS No. 4677-18-3
- Cat. No. CS-0017747
- Purity ≥97%
- MDL No. MFCD00129068
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₁₄O₂
- Molecular Weight 130.18
- Synonym(s) 2-(Tetrahydro-2H-pyran-4-yl)ethanol; 2-(Tetrahydropyran-4-yl)ethanol; 4-(2-Hydroxyethyl)tetrahydropyran; 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL
- SMILES OCCC1CCOCC1
Description
2-(Tetrahydro-2H-pyran-4-yl)ethanol features a hydroxyl-bearing ethyl linker attached to a tetrahydropyran ring, offering enhanced solubility and stability in polar reaction media. This protected alcohol integrates seamlessly into complex molecular architectures, serving as a robust building block for synthetic intermediates and functional materials.
Application
2-(Tetrahydro-2H-pyran-4-yl)ethanol serves as a versatile protecting group strategy for diols and hydroxyl functionalities, offering stable, orthogonal protection under acidic conditions. Its tetrahydropyranyl ether moiety enables selective deprotection via mild acid, while the pendant ethylene glycol handle facilitates downstream functionalization. The compound exhibits excellent bench stability, ease of purification, and compatibility with standard coupling reactions, making it a reliable building block in complex molecule synthesis.
Synthesis
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Route1
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In-stock
103260-44-2 - ~99%
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In-stock
4677-18-3
References
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Targacept, Inc. Patent: US2004/220214 A1, 2004 ;
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Route2
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In-stock
85064-61-5 - ~87%
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In-stock
4677-18-3
References
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BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; ZINDELL, Renee, M.; ERMANN, Monika Patent: WO2011/109324 A1, 2011 ; Location in patent: Page/Page column 28 ; WO 2011/109324 A1
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Route3
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In-stock
130312-00-4 - ~%
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In-stock
4677-18-3
References
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Prelog et al. Justus Liebigs Annalen der Chemie, 1937 , vol. 532, p. 80 Chem.Abstr., 1940 , p. 4396
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.46
- LogP 0.7954
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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